955959-84-9, A common heterocyclic compound, 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, molecular formula is C18H11BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 1) d.) 500 mg (1.55 mmol) 4-(4-bromophenyl)dibenzofuran, 760 mg (1 .70 mmol) 2-(9H-carbazol-3- yl)-6-phenyl-benzimidazolo[1 ,2-a]benzimidazole, 990 mg (4.64 mmol) potassium phosphate tribasic, 60 mg (0.31 mmol) copper iodide in 10 ml dioxane are stirred under nitrogen at 100¡ãC. 1.24 g (36.1 mmol) cis, trans 1 ,2-diaminocyclohexane are added. The reaction mixture is stirred for 48 h. The reaction mixture is poured in methanol. The product is filtered off and is washed with water, methanol 10 percent tatraic acid. Column chromatography on silica gel with chloroform gives the product. Yield 690 mg (65 percent) MS (APCI(pos), m/z): 691 (M+1).
The synthetic route of 955959-84-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IDEMITSU KOSAN CO., LTD.; SCHAeFER, Thomas; KAWAMURA, Masahiro; NAGASHIMA, Hideaki; (314 pag.)WO2017/56052; (2017); A1;,
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