Adding a certain compound to certain chemical reactions, such as: 460-00-4, name is 1-Bromo-4-fluorobenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 460-00-4, Recommanded Product: 460-00-4
Under nitrogen protection,Add carbazole (5 g, 30 mmol) to a 250 mL single-necked flask,P-fluorobromobenzene (10.47g, 60mmol),Cesium carbonate (21.5 g, 62 mmol) was mixed in dimethyl sulfoxide DMSO (100 mL).Reacted at 160 C for 48 hours,Cool to room temperature, extract with dichloro/water solution, and pass through the column with dichloromethane/petroleum ether.After drying in vacuo, 7.7 g of white crystals were obtained.The yield was 80%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-fluorobenzene, and friends who are interested can also refer to it.
Reference:
Patent; Jilin University; Zhang Ming; Zhang Zhaoxia; (27 pag.)CN109988097; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary