1435-53-6, The chemical industry reduces the impact on the environment during synthesis 1435-53-6, name is 2,4-Dibromo-1-fluorobenzene, I believe this compound will play a more active role in future production and life.
The 1L in three-mouth bottle, by adding benzo [d] imidazole (11.8g, 0 . 1mol), 2, 4-dibromide fluoride bonzene (51g, 0.2mol), Cs 2 CO 3 (65g, 0.2mol), N, N-dimethyl acetamide (DMA, 350g), N 2 protection, warming to reflux, thermal insulation reaction 48h, to room temperature, the reaction solution slowly into 1.4L deionized water, stirring 30 min, filtered, 400mLX2 deionized water washing, the crude product by silica gel column chromatography, eluting agent is petroleum ether: ethyl acetate = 2:1, to obtain the target compound 1-(2, 4-dibromo) phenyl-benzo [d] imidazole (compound 1a) 25.7g, yield 73%,
The chemical industry reduces the impact on the environment during synthesis 2,4-Dibromo-1-fluorobenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; The energy-Mason Co.; Sheng, Lei; Shi, Yu; Zhang, Xinxin; Gao, Ziliang; Zhang, Xueheng; Guo, Haiyan; (31 pag.)CN104109532; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary