Related Products of 129316-09-2,Some common heterocyclic compound, 129316-09-2, name is 1,3-Dibromo-5-(tert-butyl)benzene, molecular formula is C10H12Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparative Example P23Step 1 : 2-(3-Bromo-5-(tert-butyl)phenyl)propan-2-ol (P23a) To a solution of 1 ,3-dibromo-5-ferr-butylbenzene (404 mg) in dry THF (10 mL) was added n- BuLi (0.84 mL) at -78C and after 20 min, acetone was added dropwise to the above solution at -78C and the mixture was stirred at this temperature for 30 min and at rt for 1 h, diluted with sat. NH4CI and extracted with EA (3 x 30 mL). The organic layer was dried over Na2S04, evaporated and purified by CC to give compound P23a (380 mg, 70%) as a white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,3-Dibromo-5-(tert-butyl)benzene, its application will become more common.
Reference:
Patent; PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas; WO2012/139775; (2012); A1;,
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