Extended knowledge of C6H4BrF2N

The synthetic route of 67567-26-4 has been constantly updated, and we look forward to future research findings.

Reference of 67567-26-4,Some common heterocyclic compound, 67567-26-4, name is 4-Bromo-2,6-difluoroaniline, molecular formula is C6H4BrF2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-bromo-2,6-difluoroaniline (0.300g, 1.44mmol) was weighed into a vial, THF (3mL) was added. Intermediate H (407 mg, 1.44mmol) was added as a solid, followed by TEA (0.437g, 4.37 mmol). The vial was capped and the reaction was heated at 60 0C overnight. Product was precipitated by the addition of hexanes. The solids were rinsed with 2: 1 hexanes/ether to yield clean product (66%). 1H-NMR (DMSO-J6) delta 10.0 (s, IH), 9.27 (s,lH), 8.51 (d, J = 5.4 Hz, IH), 7.91 (s, IH), 7.55 (m, 2H) 7.37 (m, IH), MS [M+H]+ = 396.0, LCMS RT = 3.62 min.

The synthetic route of 67567-26-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2007/64931; (2007); A2;,
Bromide – Wikipedia,
bromide – Wiktionary