Application of 73918-56-6, These common heterocyclic compound, 73918-56-6, name is 2-(4-Bromophenyl)ethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Procedure A: The reaction mixture of 7 (17 mg, 0.05 mmol), an appropriate amine (0.3 mmol), acetic acid (17.2 muL, 0.3 mmol), and sodium cyanoborohydride (0.16mmol) in MeOH (1 mL) was stirred in a sealed pressure tube at 50C for overnight. The reaction was then cooled to room temperature and the solvent was removed under reduced pressure. The residue was purified by flash column chromatography.
The synthetic route of 73918-56-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Lin, Hao; Bruhn, David F.; Maddox, Marcus M.; Singh, Aman P.; Lee, Richard E.; Sun, Dianqing; Bioorganic and Medicinal Chemistry Letters; vol. 26; 16; (2016); p. 4070 – 4076;,
Bromide – Wikipedia,
bromide – Wiktionary