2789-89-1, name is 1,2-Bis(4-bromophenyl)ethyne, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 1,2-Bis(4-bromophenyl)ethyne
General procedure: A 25 mL Schlenk-type tube (with a Teflon high pressure valve and side arm) was charged withcompound 1a (34.6 mg, 0.10 mmol), alkynes (0.20 mmol), Cu(OAc)2.H2O (5.0 mg, 0.025 mmol),[RuCl2(p-cymene)]2 (6.1 mg, 0.01 mmol), AgSbF6 (13.7 mg, 0.04 mmol) and THF (1 mL). Thereaction tube was evacuated and back-filled with N2 (3 times, ballon). After the reaction mixturewas stirred at 120 oC for 12 h, it was allowed to cool down to room temperature. The reactionmixture was diluted with ethyl acetate (20 mL), and then filtered through a pad of Celite. Thefiltrate was washed with brine (10 mL), dried over Na2SO4, and concentrated in vacuo. Theresidue was purified by silica gel preparative TLC to give the corresponding products
The synthetic route of 2789-89-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Pan, Shulei; Jiang, Hang; Zhang, Yu; Chen, Dushen; Zhang, Yanghui; Synlett; vol. 27; 13; (2016); p. 1997 – 2002;,
Bromide – Wikipedia,
bromide – Wiktionary