Synthetic Route of 185122-74-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 185122-74-1, name is 5-Bromo-2,3-dihydro-1H-inden-1-amine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
5-bromo-2,3-dihydro-lH-inden-l -amine (2.2 g, 10.4 mmol) andSodium bicarbonate (2.6 g, 31.2 mmol)Suspended in acetonitrile (100 mL)The mixture was cooled to 0 C,To this was added Boc anhydride (3.4 mL, 15.6 mmol).The reaction mixture was stirred at room temperature overnight and concentrated under reduced pressure.The residue was taken up in ethyl acetate (100 mL) and the resulting solution was washed with water (50 mL x 2), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure.The residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate (v / v) = 20/1)The title compound was obtained as a white solid (3.3 g, 100%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-2,3-dihydro-1H-inden-1-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Wang Ruyong; Wang Liang; (112 pag.)CN104016979; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary