Reference of 393-36-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 393-36-2, name is 4-Bromo-3-(trifluoromethyl)aniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A mixture of [6-CHLORO-4-ISOPROPYL-N- (TETRAHYDROPYRAN-4-YLMETHYL)-NICOTINAMIDE] (Description 8) (100mg), [4-BROMO-3-TRIFLUOROMETHYL-] (ex Lancaster, 162mg), [METHANESULFONIC] acid [(44NL)] in 1,4-dioxane [(1MI)] was irradiated under microwave conditions at [180FOR] 30 minutes. After removal of the 1,4-dioxane under reduced pressure, the mixture was partitioned between ethyl acetate [(5ML)] and brine [(2ML)] and the aqueous layer separated. The organic layer was evaporated under reduced pressure and the residue purified using the Biotage Horizon system. Purification afforded the title compound as a white solid (47mg). NMR [(DMSO-D6)] [No.1. ]16-1.23 (8H, d, m), 1.60-1. 63 (2H, d), 1.75 (1H, m), 3.10 (2H, t), 3.28 (2H, t), 3.41 (1H, m), 3.85 (2H, d), 6.80 (1H, s), 7.73 (1H, d), 7.83 (1H, d), 8.16 (1H, s), 8.38-8. 42 (2H, m), 9.70 (1H, s). LC/MS t = 3.5 min, [MH+] 500, consistent with molecular formula [C22H2579BR F3N302]
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXO GROUP LIMITED; WO2004/29026; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary