Adding a certain compound to certain chemical reactions, such as: 24358-62-1, name is 1-(4-Bromophenyl)ethylamine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24358-62-1, Application In Synthesis of 1-(4-Bromophenyl)ethylamine
To a solution of 2-bromoacetamide 6 (827mg, 5.88 mmol), and 4-bromobenzylethylamine 15 (1.00 g, 4.90 mmol) in MeOH (5ml) and CH2Cl2 (5ml) at room temperature was added Hunig’s base (5ml). The mixture was stirred at 50-60 C for 16h. Water (30mL) was added and the mixture was extracted with CH2Cl2 (4 x 30ml) and dried over Na2SO4 to provide 1.27 g amide 16 as white crystals in 100% yield. This product was used without further purification in the next step. 1HNMR (300 MHz, CDCl3, ppm): delta 7.38 (d, J=8Hz, 2H), 7.09 (d, J=8Hz, 1H), 6.77 (s br, 1H), 5.69 (s br, 1H), 3.67 (q, J=7Hz, 1H), 3.07 (s, 2H), 1.29 (d, J=7Hz, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(4-Bromophenyl)ethylamine, and friends who are interested can also refer to it.
Reference:
Patent; RIB-X PHARMACEUTICALS, INC.; WO2005/12270; (2005); A2;,
Bromide – Wikipedia,
bromide – Wiktionary