In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 185122-74-1 as follows. Computed Properties of C9H10BrN
At 0 0C and under protective atmosphere, a solution of 2-Propanesulfonyl chloride (1 1.87 ml_, 121 mmol) in DCM (121 ml.) was added gradually to a solution of 5-bromo-2,3- dihydro-1 H-inden-1 -amine (12.8 g, 60.4 mmol) and 1 ,8-Diazabicyclo[5.4.0]undec-7-ene (4.83 ml_, 32.1 mmol) in Dichloromethane (300 ml_). The reaction was stirred at rt overnight. The reaction mixture was washed with 1 N KHSO4 (1x) and sat NaHCObeta (2x) before being dried on Na2SO4 and solvent evaporated in vacuo to afford a green oil. Purification by column chromatography (25% EtOAc in heptane) afforded the title compound as a white solid.(6.0 g, 31 %). MS (ESI) : m/z [M – H]” 317.0
According to the analysis of related databases, 185122-74-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; N.V. Organon; GILLEN, Kevin James; GILLESPIE, Jonathan; JAMIESON, Craig; MACLEAN, John Kinnaird Ferguson; MOIR, Elizabeth Margaret; RANKOVIC, Zoran; WO2010/115952; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary