Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 583-75-5, name is 4-Bromo-2-methylaniline, A new synthetic method of this compound is introduced below., Formula: C7H8BrN
Adding the compound 183a (1.0 g, 5.37 mmol),Compound 183b (2.73 g, 10.75 mmol),Potassium acetate (1.58 g, 16.12 mmol) and PdCl2 (dppf) (0.39 g, 0.54 mmol) were added to 1,4-dioxane (20 mL), replaced with nitrogen three times, and then stirred at 90 C for 4 hours. The reaction solution was cooled to room temperature and filtered.The filter cake was washed with ethyl acetate (15 mL × 2), and the filtrate was concentrated.The concentrate was purified by silica gel chromatography (ethyl acetate: petroleum ether = 0-80%) to obtain a compound 183c as a yellow solid, namely , 2-Dioxoranepentyl-2-yl) aniline (1.21 g, 96.6% yield).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Jiaxing Tekeluo Biological Technology Co., Ltd.; Xing Li; Li Guanqun; Wang Xiaolei; Cai Yuting; Jiang Xiang; Pan Xiang; Zhu Wenhao; Wang Yang; Wang Zengquan; (83 pag.)CN110627775; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary