Some common heterocyclic compound, 68322-84-9, name is 2-Bromo-1-fluoro-4-(trifluoromethyl)benzene, molecular formula is C7H3BrF4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-Bromo-1-fluoro-4-(trifluoromethyl)benzene
Step F 3- 4- [3- (2-Bromo-4-trifluoromethyl-phenoxy)-5-fluoro-phenoxy]-2-methyl-phenyl}- propionic acid ethyl ester A mixture of 3- [4- (3-fluoro-5-hydroxy-phenoxy)-2-methyl-phenyl]- propionic acid ethyl ester (0.557 g, 1.75 mmol), 3-bromo-4-fluorobenzotrifluoride (0.425 g, 1.75 mmol) and 325 mesh potassium carbonate (0.29 g, 2.10 mmol) in dry DMSO (10 mL) is heated to 100 C and stirred 2.5 hours under N2. The reaction is cooled and acidified with 1 N HCI. The mixture is then diluted with Et20 and extracted with water. The organic layer is dried (Na2S04), and the solvent is removed in vacuo to afford crude product that is absorbed on silica gel and purified by flash chromatography using 5/1 hexanes/ethyl acetate to afford 0.735 g (78%) of the title compound.’H NMR (400 MHz, CDCl3) ; MS (ES+) 7w/Z mass calculated for C25H2104F4Br 540, found 558 and 560 (M + NH4, 100%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 68322-84-9, its application will become more common.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/37763; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary