Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1003-98-1, name is 2-Bromo-4-fluoroaniline, This compound has unique chemical properties. The synthetic route is as follows., category: bromides-buliding-blocks
Step 1: 2-(2-Bromo-4-fluorophenyl)hydrazinium chlorideTo a suspension of 2-bromo-4-fluoroaniline in concentrated HCl (1.5M) at -10 0C was slowly added a 10.0M aqueous solution OfNaNO2 (1.1 eq). The mixture was stirred at O 0C for 2.5 hrs. A cold (-30 C) solution Of SnCl2 (3.8M) in concentrated HCl was then slowly added while maintaining the internal temperature below 10 0C. The resulting mixture was stirred mechanically for 20 mm at 10 C, then at room temperature for 1 hr. The thick slurry was filtered and the solid was air dried overnight. The solid was resuspended in cold HCl and filtered again. The dried material was suspended in Et2O, stirred for 10 min, filtered and air dried overnight to give the title compound as a beige solid
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1003-98-1.
Reference:
Patent; MERCK & CO., INC.; WO2006/89309; (2006); A2;,
Bromide – Wikipedia,
bromide – Wiktionary