In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 393-36-2, name is 4-Bromo-3-(trifluoromethyl)aniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 393-36-2
Preparation of 3-trifluoromethyl-4-vinylaniline 4-Bromo-3-(trifluoromethyl)aniline (4.0 g, 16.7 mmol) was dissolved in isopropanol (20 mL), water (10 mL), and t-butylamine (5 mL). To the solution, potassium(trifluoro)vinylborate (4.0 g, 29.9 mmol), PdCl2(dppf)2ยท2-dichloromethane complex (300 mg, 0.37 mmol) were added. The resulting mixture was stirred under argon atmosphere at 80C for 20 hours and then concentrated. The residue was partitioned between water and ethyl acetate, and the organic layer was washed with saturated brine and concentrated under reduced pressure. The resulting product was purified by silica-gel column chromatography (n-hexane: ethyl acetate = 6:1) to give 3-trifluoromethyl-4-vinylaniline (2.475 g, 79%) as a light-yellow oil. 1H-NMR (270MHz, CDCl3) delta (ppm): 3.84 (2H, s), 5.20 (1H, dd, J=1.8, 10.9Hz), 5.56 (1H, d, J=17.1Hz), 6.78 (1H, dd, J=10.9, 17.1Hz), 6.88-7.04 (2H, m), 7.48 (1H, d, J=8.4Hz).
The synthetic route of 393-36-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CHUGAI SEIYAKU KABUSHIKI KAISHA; The University of Tokyo; EP1921078; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary