In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22385-77-9, name is 1-Bromo-3,5-di-tert-butylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 1-Bromo-3,5-di-tert-butylbenzene
Bis(pinacolato)diboron (6.89 g, 27.1 mmol) , KOAc (7.01 g, 71.4 mmol), 13 (5.62 g, 20.9 mmol) and 25 mL of dioxane were sparged with Ar for 1 h. Pd(dppf)Cl2 (341 mg, 0.418 mmol) was added and the reaction was sparged for an additional 20 min. The reaction was then refluxed overnight. The reaction was then cooled to room temperature and quenched with 50 mL of sat. NH4Cl and diluted with 75 mL of distilled water and extracted 3 x with 75 mL of Et2O. The combined organics were washed with 75 mL of water and 75 of brine, dried with magnesium sulfate, treated with activated charcoal, and filtered in through a pad of celite. The solvents were removed under vacuum. The product was isolated with column chromatography to afford a white solid (3.31 g, 50percent), mp 175-178 C (lit.7 mp 179 C). 1H NMR (CDCl3): delta 7.67 (s, 2H), 7.55 (s, 1H), 1.35 (s, 30H). The 1H NMR matches the known spectrum.7
The synthetic route of 22385-77-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Dressler, Justin J.; Miller, Sarah A.; Meeuwsen, Brian T.; Riel, Asia Marie S.; Dahl, Bart J.; Tetrahedron; vol. 71; 2; (2015); p. 283 – 292;,
Bromide – Wikipedia,
bromide – Wiktionary