Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 875664-38-3, name is 1-Bromo-4,5-difluoro-2-methylbenzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H5BrF2
General procedure: To a solution of o—dibromobenzenes, N—Boc—pyrrole—2—boronic acid 2 and 1.0 M K2CO3aq. in DMF was added PdCl2(PPh3)2 (20%/mol) under a nitrogen atmosphere. Theresulting mixture was heated at 80 C for 7 h. After cooling to room temperature, themixture was extracted with a mixture of EtOAc/hexane (v/v = 1:4). The organic layerwas washed with water and brine, and then dried over Na2SO4. After removal solvent,the residue was purified by silica gel column chromatography and recrystallization todi(N—Boc—pyrrol—2—yl—benzenes).
The synthetic route of 875664-38-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kuzuhara, Daiki; Miyake, Satoshi; Moriyama, Hirotake; Tamura, Yuto; Aratani, Naoki; Yamada, Hiroko; Tetrahedron Letters; vol. 56; 41; (2015); p. 5564 – 5567;,
Bromide – Wikipedia,
bromide – Wiktionary