Reference of 3722-78-9, The chemical industry reduces the impact on the environment during synthesis 3722-78-9, name is 8-Bromochroman, I believe this compound will play a more active role in future production and life.
Example 10 8-(4,4,5,5-Tetramethyl-l,3,2-dioxaborolan-2-yl)chromane 8-Bromochromane (described in Gerard H. Thomas et al. Tetrahedron. Lett. 1998, 39, 2219-2222, 426 mg, 2 mmol), 4,4,4′,4I,5,5,5′,51-octamethyl-2,2′-bi-l,3,2-dioxaborolane (609 mg, 2.4 mmol), [l,r-bis(diphenylphosphino)ferrocene]palladium(II) chloride dichloromethane adduct (50 mg, 0.06 mmol), potassium acetate (590 mg, 6 mmol) and 1,2- dimethoxyethan (3 mL) was irradiated in a microwave at 150 0C for 15 min. When cooled to ambient temperature the mixture was diluted with water (5 mL) and extracted with diethyl ether (3 x 20 mL). The crude product was purified by flash chromatography, using dichloromethane/methanol (95:5) as the eluent, to give 290 mg (56% yield) of the title compound. 1H-NMR (400 MHz5 OMSO-d6): delta 7.32 (dd, J = 7.3, 1.5 Hz, IH), 7.12 (dd, J = 7.4, 1.6 Hz, IH), 6.76 (t, J = 7.4 Hz5 IH)54.12 (t, J = 5.0 Hz52H)5 2.71 (t, J = 6.5 Hz52H), 1.92-1.84 (m, 2H), 1.25 (s, 12H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 8-Bromochroman, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; ASTEX THERAPEUTICS LTD; WO2007/73284; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary