Some common heterocyclic compound, 927384-44-9, name is 2-(4-Bromophenyl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine, molecular formula is C16H12BBrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C16H12BBrN2
A suspension of 1,8-diaminonaphthalene protected p-bromobenzeneboronic acid (1.61 g, 5.0mmol), B2pin2 (1.90 g 7.5 mmol), KOAc (1.47 g, 15.0 mmol) and PdCl2(dppf) (204 mg, 0.25mmol) in DMF (100 mL) was stirred at 80 C for 3 h. The mixture was extracted with EtOAc and washed with brine. The organic layer was separated and dried over Na2SO4. The solvent was removed under reduced pressure, and the residue was purified by column chromatography on silica gel (EtOAc), preparative SEC using CHCl3 as the eluent, and recrystallization (CH2Cl2-Hexane) to give 18 as a white solid (1.34 g, 72%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 927384-44-9, its application will become more common.
Reference:
Article; Terao, Jun; Konoshima, Yohei; Matono, Akitoshi; Masai, Hiroshi; Fujihara, Tetsuaki; Tsuji, Yasushi; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 2800 – 2808;,
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