In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 89523-51-3 as follows. Product Details of 89523-51-3
(A-4) Synthesis of benzo(c)phenanthrene-5-boronic acid Under the atmosphere of argon, 10.1g of 5-bromobenzo[c]phenanthrene was placed in a flask, and 400 mL of dehydrated ether was added. The reaction solution was cooled to -40C, and 22 mL of a hexane solution of 1.6 M n-butyl lithium was added. The resultant was heated to 0C, and stirred for 1 hour. The reaction solution was cooled to -60C, and 10 mL of a dehydrated ether solution of 14.4g of triisopropyl borate was added dropwise. While heating the reaction solution to room temperature, stirring was continued for 5 hours. 10 mL of a 10% aqueous hydrochloric acid solution was added, followed by stirring for 1 hour. An aqueous phase was removed, and an organic phase was washed with water and saturated saline, and dried with magnesium sulfate. After filtering off magnesium sulfate, the organic phase was concentrated. The resulting solids were washed with hexane, whereby 5.37g (yield 60%) of benzo[c]phenanthrene-5-boronic acid as an intended product was obtained.
According to the analysis of related databases, 89523-51-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2524913; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary