Reference of 105309-59-9, A common heterocyclic compound, 105309-59-9, name is Tetrakis(4-bromophenyl)methane, molecular formula is C25H16Br4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A solution of Ar-X (2.0 mmol), TeocNHOTBS (3; 640 mg, 2.2 mmol), Bippyphos (2; 51 mg, 0.10 mmol), and Pd2dba3 (23 mg, 0.025 mmol) in toluene (8 mL) was treated with Cs2CO3 (1.3 g, 4.0 mmol). N2 was bubbled through the mixture for 30 min, and then the mixture was heated and stirred at 80 C for 16 h under N2. The resulting mixture was purified directly by column chromatography (EtOAc/hexanes).
The synthetic route of 105309-59-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Beaudoin, Daniel; Wuest, James D.; Tetrahedron Letters; vol. 52; 17; (2011); p. 2221 – 2223;,
Bromide – Wikipedia,
bromide – Wiktionary