A common heterocyclic compound, 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, molecular formula is C12H6Br2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 10016-52-1.
To a 1 L reaction flask was added toluene solvent (450 ml), 2,8-dibromodibenzofuran (11.74 g, 36 mmol),Intermediate I-21 (36.22 g, 90 mmol), Pd2 (dba) 3 (990 mg, 1.08 mmol),BINAP (1.65 g, 16.5 mmol) and sodium tert-butoxide (9.9 g, 100.8 mmol),Dissolved by stirring, and refluxed under nitrogen for 24 hours.After completion of the reaction, the reaction solution was washed with dichloromethane and distilled water and then evaporated.The organic layer was dried over anhydrous magnesium sulfate. After filtered, solvent was removed, and purified by column chromatography using cyclohexane: ethyl acetate = 10:1 as eluent.Finally, solid compound 21 (25.81 g, yield 74%) was obtained, and the solid purity was 99.6% by HPLC.
The synthetic route of 2,8-Dibromodibenzo[b,d]furan has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Zhao Qian; Liu Hui; Han Chunxue; (55 pag.)CN110407829; (2019); A;,
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