In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 117635-21-9 as follows. SDS of cas: 117635-21-9
1,4-dibromo-2,5-dihexyl benzene (8.05 mmoles, 3.255g), boronic ester 26 (17.7 mmoles, 7.545g), Na2CO3 (40.3 mmoles, 4.268g) and Aliquat 336 (0.500g) were suspended in toluene (100 mL) in a 250 mL two-necked- round-bottom-flask with stir bar and condenser. The reaction mixture degassed and Pd(PPh3)4 (0.403 mmoles, 0.465g) added followed by addition of degassed water (50 mL). Reaction heated to 90C for two days. Resulting reaction mixture diluted with ethyl acetate (150 mL), washed with ethyl acetate (3 x 100 mL). Organic layer washed with brine (2 x 100 mL), dried over magnesium sulfate, filtered and concentrated. Purification by column chromatography on silica gel using 1 :3 DCM: Hexanes to yield white powder (56%, 3.8g). 1 H NMR (500 MHz, CD2CI2) delta = 7.45 (d, J = 8.5Hz, 4H), 7.33-7.31 (m, 5H), 7.26-7.19 (m, 5H), 6.65 (s, 2H), 2.71 -2.63 (m, 9H0, 1 .54 (s, 18H), 1 .31 -1 .20 (m, 14H), 1 .15 (t, J = 7.49, 7H), 0.83 (t, J = 6.85Hz, 6H).
According to the analysis of related databases, 117635-21-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; PARK, Kyung-Ho; RADU, Nora, Sabina; JOHANSSON, Gary, A.; FENNIMORE, Adam; DELANEY, William, J.; LECLOUX, Daniel, David; WO2011/159872; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary