58971-11-2, name is 3-Bromophenethylamine, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 58971-11-2
A mixture of 3-bromobenzeneethanamine (9.70 g, 48,5 mmole) and 2,6-lutidine (5.8 ml, 50.0 mmole) in dry CH2Cl2 (150 ml) was cooled to 0 0C. Trifluoroacetic anhydride (5.6 ml, 40 mmole) was added dropwise; the reaction was then warmed to room temperature and allowed to stir for 24 hours. Water (120 ml) was added to the reaction, the phases were separated, and the aqueous layer was extracted with CH2Cl2 (2 x 100 ml). The combined organic phases were washed successively with IN HCl (100 ml) and saturated NaHCO3 (100 ml), and then dried over Na2SO4, filtered, and concentrated in vacuo to provide the tile compound (12.3 g, 86%). The crude compound was used in subsequent steps. 1H NMR (400 MHz, CDCl3) delta 7.40 (d, J=8.0 Hz, IH), 7.36 (s, IH), 7.21 (t, J=7.6 Hz, IH), 7.12 (t, J=7.6 Hz, IH), 6.31 (br s, IH), 3.59 (q, J-6.8 Hz, 2H)5 2.87 (t, JK7.2 Hz, 2H).
Statistics shows that 58971-11-2 is playing an increasingly important role. we look forward to future research findings about 3-Bromophenethylamine.
Reference:
Patent; PREDIX PHARMACEUTICALS HOLDINGS, INC.; WO2007/61458; (2007); A2;,
Bromide – Wikipedia,
bromide – Wiktionary