Reference of 393-36-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 393-36-2, Name is 4-Bromo-3-(trifluoromethyl)aniline, SMILES is C1=C(N)C=CC(=C1C(F)(F)F)Br, belongs to bromides-buliding-blocks compound. In a article, author is Jiang, Zhe, introduce new discover of the category.
MiR-148b suppressed non-small cell lung cancer progression via inhibiting ALCAM through the NF-kappa B signaling pathway
Background Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. MiRNAs are recognized as important molecules in cancer biology. The aim of the study was to identify a novel biomarker miR-148b and its mechanism in the modulation of NSCLC progression. Methods The expressional level of miR-148b was analyzed by RT-PCR. The effect of miR-4317 on proliferation was evaluated through 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2Htetrazolium bromide (MTT) assay. The effect of miR-148b on the metastasis of NSCLC was detected through transwell assays. The verification of the target of miR-148b was assessed by TargetScan and dual-luciferase reporter assay. The related proteins in this study were analyzed by western blot. Results Our findings confirmed that miR-148b was decreased in NSCLC and NSCLC patients with lower expression exhibited poorer overall survival (OS). Increasing miR-148b significantly repressed proliferation, invasion and migration. More importantly, activated leukocyte cell adhesion molecule (ALCAM) was determined as the direct target of miR-148b, and reintroduction of ALCAM attenuated miR-148b effect on the progress of NSCLC. In addition, NF-kappa B signaling pathway was modulated by miR-148b/ALCAM axis. Conclusions Our results indicated that miR-148b is able to suppress NSCLC growth and metastasis via targeting ALCAM through the NF-kappa B pathway. These findings provided new evidence that miR-148b serves as a potential biomarker and novel target for NSCLC treatment.
Reference of 393-36-2, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 393-36-2.