Adding some certain compound to certain chemical reactions, such as: 3972-65-4, name is 1-Bromo-4-(tert-butyl)benzene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3972-65-4. 3972-65-4
General procedure: An oven-dried 10 mL reaction vial equipped with a stir bar was charged with Pd(OAc)2 (1.12mg, 0.005 mmol) and 3a (2.7 mg, 0.0075 mmol) under a nitrogen atmosphere, and 0.5 mL of dry toluene was added to the mixture. After stirring for 5 min at room temperature, NaN(SiMe3)2 (55 mg, 0.3 mmol, 3 equiv) was added to the reaction vial. After stirring for another 15 min at room temperature, 4-benzylpyridine (20.3 mg, 0.12 mmol, 1.2 equiv) was added to the reaction mixture followed by 1-bromo-4-tert-butylbenzene (21.3 mg, 0.1 mmol, 1 equiv). The reaction mixture was stirred for 16 h at 60 C, quenched with two drops of H2O, diluted with 3 mL of ethyl acetate, and filtered over a pad of MgSO4 and silica. The pad was rinsed with additional ethyl acetate, and the solution was concentrated in vacuo. The crude material was loaded onto a silica gel column and purified by flash chromatography.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1-Bromo-4-(tert-butyl)benzene.
Reference:
Article; Zhou, Bi-Hui; Wu, Chen; Chen, Xing-Xiu; Huang, Hong-Xia; Li, Lin-Lin; Fan, Li-Mei; Li, Jie; Tetrahedron Letters; vol. 58; 44; (2017); p. 4157 – 4161;,
Bromide – Wikipedia,
bromide – Wiktionary