Adding some certain compound to certain chemical reactions, such as: 615-54-3, name is 1,2,4-Tribromobenzene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 615-54-3. 615-54-3
Under a nitrogen stream, 16.9 g (0.10 mol) of Exemplified Compound 1-1 was dissolved in 390 m of dehydrated THF, adjusted to -5 C. with an ice-water bath, and 59.4 ml of 1.6M nBuLi (¡Á 0.95 mol ratio to Exemplified Compound 1). -1) was added dropwise for 10 min (the water content of THF was measured by a coulometric titration method and found to be 15 ppm. This corresponds to 3.25 ¡Á 10 -4 mol of water molecules and a corresponding amount of 1.6 M nBuLi solution 0 20 ml was added as a correction amount.) After stirring for 1 hour, 18.6 g of Exemplified Compound 2-7 was added dropwise over 10 min and stirred for 1 hour.During this time, the internal temperature was -10 C to 5 C.480 ml of THF, exemplary compound 4-5A solution prepared by dissolving 9.5 g and 16.8 g of potassium carbonate in 30 ml of pure water was added in this order, and nitrogen bubbling was performed for 20 minutes. To this suspension, 2.7 g of Pd (dba) 2 and 1.8 g of Exemplified Compound 10-1 were added and refluxed for 6 hours. After washing with saturated brine, the solvent was distilled off under reduced pressure. Recrystallization from cyclohexane gave 14.2 g of gray crystals (yield 81%, purity 99.3%).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1,2,4-Tribromobenzene.
Reference:
Patent; Konica Minolta Co., Ltd.; Sugita, Shuichi; Okubo, Kimihiko; Nishimura, Hiroshi; Hagiwara, Toshiyuki; (38 pag.)JP2019/99537; (2019); A;,
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