Chemistry is an experimental science, Name: 1-Bromo-2-nitrobenzene, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 577-19-5, Name is 1-Bromo-2-nitrobenzene, molecular formula is C6H4BrNO2, belongs to bromides-buliding-blocks compound. In a document, author is Liu, Xue-Wen.
Topo I inhibition, DNA photocleavage, Molecular docking and cytotoxicities of two new phenanthroline-based ruthenium complexes
Two ruthenium complexes containing a new phenanthroline-based ligand pai (pai = 2-(5-(1, 10- phenanthroline))-1H-acenaphtho[1 ‘,2 ‘:4,5]imidazole) were synthesized and characterized. Two ruthenium complexes were found to cleave DNA under irradiation, interact with CT-DNA by intercalation. Furthermore, DNA topoisomerase inhibition experiments indicated that complex 2 exhibited higher topoisomerase I inhibition activity (IC50 = 10 mu M) than complex 1 (IC50 = 40 mu M). Molecular modeling studies revealed that complex 2 stabilized Top1cc complex via pi-pi interaction and the formation of hydrogen bond. The cytotoxicity of complexes 1 and 2 against Eca-109 and A549 cells was also evaluate by MTT method, indicating that complex 2 exhibited good anticancer activity against Eca-109 cells (IC50 = 17.23 +/- 0.22 mu M), but two ruthenium complexes displayed weak anticancer activity against A549 cells.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 577-19-5, in my other articles. Name: 1-Bromo-2-nitrobenzene.