91-13-4, Name is 1,2-Bis(bromomethyl)benzene, molecular formula is C8H8Br2, Name: 1,2-Bis(bromomethyl)benzene, belongs to bromides-buliding-blocks compound, is a common compound. In a patnet, author is Yang, Ping, once mentioned the new application about 91-13-4.
Copper(ii) complexes with NNO ligands: synthesis, crystal structures, DNA cleavage, and anticancer activities
Three novel copper(ii) complexes, Cu(L1)(2) (1), Cu(L2)(2)2DMF (2), and Cu(L3)(2)2DMF (3), were synthesized using three aroylhydrazone ligands, (E)-2-hydroxy-N ‘-(1-(pyrazin-2-yl)ethylidene)benzohydrazide (HL1), (E)-3-hydroxy-N ‘-(1-(pyrazin-2-yl)ethylidene)benzohydrazide (HL2) and (E)-4-hydroxy-N ‘-(1-(pyrazin-2-yl)ethylidene)benzohydrazide (HL3). The complexes were characterized by elemental analysis, infrared (IR), and Ultraviolet-visible light (UV-vis) spectroscopy. The X-ray crystal structures of the complexes all possess a distorted octahedral coordination geometry. Both an absorption spectral titration and a competitive binding assay (ethidium bromide, 4 ‘,6-diamidino-2-phenylindole (DAPI), and methyl green) revealed that complexes 2 and 3 bind readily to calf thymus DNA (ctDNA) through intercalative and minor groove binding modes. Complexes 2 and 3 also exhibited oxidative cleavage of supercoiled plasmid DNA (pUC19) in the presence of ascorbic acid as an activator. Cytotoxicity studies showed that complexes 2 and 3 possessed high cytotoxicities toward the HeLa human cervical cancer cell line, but weak toxicities toward the L929 normal mouse fibroblast cell line. We therefore have reason to believe that complexes 2 and 3 both show potential as promising anticancer candidate drugs.
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