38573-88-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 38573-88-5, name is 1-Bromo-2,3-difluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 2Preparation of (4-bromo-2,3-difluorophenyl)trimethylsilaneDiisopropylamine (7.86 grams (g), 78 mmol) was dissolved in tetrahydrofuran (THF; 104 mL) and cooled to -75¡ã C. utilizing a dry ice/acetone bath.A solution of n-BuLi (2.5 M in hexanes; 22.80 mL, 57.0 mmol) was added dropwise, and the solution was again cooled to -75¡ã C. 1-Bromo-2,3-difluorobenzene (10 g, 51.8 mmol) was dissolved in THF (25.9 mL), and the solution was added dropwise keeping the temperature below -60¡ã C.The reaction mixture was then allowed to warm to -15¡ã C. before cooling again to -75¡ã C. TMSCl (7.29 mL, 57.0 mmol) was then added dropwise, and the reaction mixture was allowed to warm to 25¡ã C. and then concentrated under vacuum.The residue was partitioned between ethyl acetate (EtOAc) and H2O.The organic phase was washed twice more with H2O and concentrated.Kugelrohr distillation at 88¡ã C. provided the product in greater purity but an impurity was distilling at that temperature.Kugelrohr distillation of that purified distillate at 75¡ã C. led to purer product but some product was left in the pot.This process yielded the title compound as a clear oil (3.0 g, 21.83percent, 90percent purity): 1H NMR (300 MHz, CDCl3) delta 7.28 (ddd, J=7.8, 5.2, 1.3 Hz, 1H), 6.98 (ddd, J=8.0, 4.8, 1.9 Hz, 1H), 0.32 (s, 9H); EIMS m/z 264, 266.
The synthetic route of 38573-88-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Epp, Jeffrey B.; Lowe, Christian T.; Renga, James M.; Schmitzer, Paul R.; Eckelbarger, Joseph D.; Guenthenspberger, Katherine A.; Siddall, Thomas L.; Yerkes, Carla N.; Fischer, Lindsey G.; Giampietro, Natalie C.; Kister, Jeremy; Roth, Joshua; US2013/5574; (2013); A1;,
Bromide – Wikipedia,
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