955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 955959-84-9
In a stream of argon, 5.9 g of acetamide, 32.3 g of the intermediate 3 , 2.70 g of copper iodide, 40.8 g of potassium carbonate, 6.3 g of N’N-dimethylethylenediamine, and 300 mL of xylene were loaded, and then the mixture was subjected to a reaction at 175¡ãC for 19 hours. Further, 38.5 g of the intermediate 1 were loaded into the resultant, and then the mixture was subjected to a reaction at 175¡ãC for 19 hours. After the resultant had been cooled, water was added so that the resultant was filtrated. The residue was washed with acetone, methanol, and water three times each. Thus, 28.4 g of an acetamide body of the intermediate 13 were obtained. 28.4 g of the acetamide body of the intermediate 13, 26.3 g of potassium hydroxide, 25 mL of water, and 40 mL of xylene were loaded, and then the mixture was subjected to a reaction at 175¡ãC for 5 hours. After the resultant had been cooled, water was added so that the resultant was filtrated. The residue was washed with acetone, methanol, and water three times each, and was then purified with a short column (developing solvent: toluene). The resultant solid was washed with n-hexane and dried under reduced pressure. Thus, 16.6 g of a white solidwere obtained. The white solidwas identified as the intermediate 13 by FD-MS analysis.
The synthetic route of 955959-84-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2502908; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary