Polyamide-Scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal was written by Lo, Anthony T. S.;Salam, Noeris K.;Hibbs, David E.;Rutledge, Peter J.;Todd, Matthew H.. And the article was included in PLoS One in 2011.HPLC of Formula: 1196-90-3 This article mentions the following:
Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time through a synthetically facile copper-catalyzed “click” reaction. The corresponding copper and zinc complexes were synthesized and characterized. The ligand and its complexes bound AT-rich DNA selectively over GC-rich DNA, and the thermodn. profile of the binding was evaluated by isothermal titration calorimetry. The metal, encapsulated in a scorpion azamacrocyclic complex, did not affect the binding, which was dominated by the organic tail. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate (cas: 1196-90-3HPLC of Formula: 1196-90-3).
Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate (cas: 1196-90-3) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.HPLC of Formula: 1196-90-3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary