Synthetic Route of 88223-35-2, These common heterocyclic compound, 88223-35-2, name is 2-Bromo-9,9-dibutyl-9H-fluorene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of benzoyl chloride (1.05 ml; 13.5 mmol), AlCl3 (2 g; 15 mmol) and2-bromo-9,9-dibutyl-9H-fluorene (4.0 g; 9.0 mmol) in CS2 (80 mL) was prepared and purged with argon. Themixture was stirred for 16 h under argon. After the solvent was evaporated, the aqueous layer was extractedwith DCM. The combined organic layer was washed with water and dried over MgSO4. The residue waspurified by column chromatography on silica gel (hexane : DCM = 1 : 1).Yield: white solid (415 mg; 9.0 mmol; 99 %).1H-NMR (300 MHz, DMSO-d6): delta 7.84-7.73 (m, 5H), 7.65-7.58 (m, 2H), 7.52-7.48 (m, 4H), 2.07-1.89 (m, 4H),1.16-1.03 (m, 4H), 0.68 (t, 6H), 0.66-0.54 (m, 4H).
Statistics shows that 2-Bromo-9,9-dibutyl-9H-fluorene is playing an increasingly important role. we look forward to future research findings about 88223-35-2.
Reference:
Article; Wada, Atsushi; Nishida, Jun-Ichi; Maitani, Masato M.; Wada, Yuji; Yamashita, Yoshiro; Chemistry Letters; vol. 43; 3; (2014); p. 296 – 298;,
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