Adding a certain compound to certain chemical reactions, such as: 937046-98-5, name is 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 937046-98-5, Application In Synthesis of 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine
To a solution of 2-1 (3.85 g, 18.1 mmol, WO 2007/64931, published June 7, 2007) in anhydrous DMF (30 mL) was added NaH (1.08 g, 27.1 mmol) at 0 C. The reaction was stirred under N2 for 0.5 h. MMTrCl (6.14 g, 19.9 mmol) was added. The mixture was stirred at RT for 2 h. Water was added to quench the reaction. The mixture was extracted with EA (3 X 100 mL). The organic phase was combined and then dried over Na2SO4. After filtration, the solution was concentrated in vacuo to give a residue which was further purified by column chromatograph (PE:EA = 20: 1) to give 2-2 (3.8 g, 45%) as a white solid. ESI-LCMS: m/z 485.2 [M+H]+
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ALIOS BIOPHARMA, INC.; BEIGELMAN, Leonid; WANG, Guangyi; ZHONG, Minghong; (249 pag.)WO2017/156262; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary