Synthesis and resolution of DL-phenylalanine analogues was written by Liu, Jinchun;Song, Bowen;Ma, Yu;Cai, Jun;Li, Tingyou. And the article was included in Nanjing Yike Daxue Xuebao, Ziran Kexueban in 2013.COA of Formula: C9H11Br This article mentions the following:
L-2,6-dimethylphenylalanine and L-2,4,6-trimethylphenylalanine were synthesized through enzymic resolution Racemic 2,6-dimethylphenylalanine and 2,4,6-trimethylphenylalanine were synthesized through reaction of di-Et acetamidomalonate with 2,6-dimethylbenzyl bromide or 2,4,6-trimethylbenzyl bromide, resp. The DL-amino acids were then enzymically resolved by L-amino acylase. Racemic 2,6-dimethylphenylalanine and 2,4,6-trimethylphenylalanine were synthesized through reaction of di-Et acetamidomalonate with 2,6-dimethylbenzyl bromide and 2,4,6-trimethylbenzyl bromide in yield of 87.9% and 86.0% resp. DL-2,6-dimethylphenylalanine was successfully resolved by L-amino acylase, but it was failed in the resolution of 2,4,6-trimethylphenylalanine. L-amino acylase can be used in the resolution of DL-2,6-dimethylphenylalanine, but it is ineffective in the resolution of 2,4,6-trimethylphenylalanine. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7COA of Formula: C9H11Br).
2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. COA of Formula: C9H11Br
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary