Synthesis of polycitrin A and 3,4-bis(4-hydroxyphenyl)pyrrole derivatives related to polycitone A was written by Winklhofer, Christian;Terpin, Andreas;Peschko, Christian;Steglich, Wolfgang. And the article was included in Synthesis in 2006.Name: 3,5-Dibromo-4-methoxybenzaldehyde This article mentions the following:
The oxidative condensation of 3-arylpyruvic acids, e.g. I, with arylethylamines, e.g. 4-MeOC6H4CH2CH2NH2, to give 3,4-diarylpyrrole-2,5-dicarboxylic acids, e.g. II (R = OH) , was used for an efficient synthesis of polycitrin A (III). Investigation of the bromine-mediated degradation of acid II (R = OH) to maleimide IV (R12 = O) suggested that the corresponding 2,5-dibromopyrrole and 5,5-dimethoxy-3-pyrroline-2-one IV (R1 = MeO) are intermediates in this process. The debromo analog of polycitone A V was prepared in two steps from pyrrole dicarboxylic acid diester II (R = EtO). In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Name: 3,5-Dibromo-4-methoxybenzaldehyde).
3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: 3,5-Dibromo-4-methoxybenzaldehyde
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary