Synthetic Route of 7051-34-5, A common heterocyclic compound, 7051-34-5, name is (Bromomethyl)cyclopropane, molecular formula is C4H7Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A 15 g quantity of methyl 3-hydroxy-4-methoxybenzoate obtained in Reference Example 1 was dissolved in 150 ml of dimethylformamide, and 34 g of potassium carbonate and 22.2 g of (bromomethyl) cyclopropane were added. The mixture was heated at 9O0C overnight. Ice water was added to the reaction mixture, and the precipitated crystals were collected by filtration and washed with an excess of water. The obtained crystals were dried under reduced pressure at room temperature to give 18.3 g of white crystalline methyl 3-cyclopropylmethoxy-4-methoxybenzoate. 1H-NMR (CDCl3) delta: 7.67 (IH, dd, J = 8.4, 1.8 Hz), 7.52 (IH, d, J = 2.1 Hz), 6.89 (IH, d, J = 8.4 Hz), 3.94-3.86 (8H, m) , 1.43-1.29 (IH, m), 0.70-0.58 (2H, m) , 0.45-0.30 (2H, m)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; WO2007/58338; (2007); A2;,
Bromide – Wikipedia,
bromide – Wiktionary