Discovery and structure-activity relationships of spiroindolines as novel inducers of oligodendrocyte progenitor cell differentiation was written by Katayama, Katsushi;Arai, Yoshikazu;Murata, Kenji;Saito, Shoichi;Nagata, Tsutomu;Takashima, Kouhei;Yoshida, Ayako;Masumura, Makoto;Koda, Shuichi;Okada, Hiroyuki;Muto, Tsuyoshi. And the article was included in Bioorganic & Medicinal Chemistry in 2020.Name: 4-Amino-3-bromophenol This article mentions the following:
A novel series of spiroindoline derivatives was discovered for use as inducers of oligodendrocyte progenitor cell (OPC) differentiation, resulting from optimization of screening hit 1. Exploration of structure-activity relationships led to compound 18, which showed improved potency (rOPC EC50 = 0.0032娓璏). Furthermore, oral administration of compound 18 significantly decreased clin. severity in an exptl. autoimmune encephalomyelitis (EAE) model. In the experiment, the researchers used many compounds, for example, 4-Amino-3-bromophenol (cas: 74440-80-5Name: 4-Amino-3-bromophenol).
4-Amino-3-bromophenol (cas: 74440-80-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: 4-Amino-3-bromophenol
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary