Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 134168-97-1, name is 3-Bromo-5-fluoroaniline, A new synthetic method of this compound is introduced below., COA of Formula: C6H5BrFN
To a mixture of 4-(4-(pyrimidin-2-yl)piperazin-1-yl)dihydrofuran-2(3H)-one (100 mg) and 3-bromo-5-fluoroaniline (92 mg) in toluene (1 mL) was added bis(trimethylaluminum)-1,4-diazabicyclo[2.2.2]octane adduct (61.9 mg) at room temperature and the mixture was stirred at 80 C. for 30 min. The reaction mixture was diluted with THF and quenched with sodium sulfate decahydrate (545 mg) at room temperature. The insoluble material was removed by filtration, and the filtrate was concentrated in vacuo. The residue was purified by column chromatography (silica gel, methanol/ethyl acetate) to give the title compound (80 mg). MS: [M+H]+ 438.1.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KOIKE, Tatsuki; FUSHIMI, Makoto; AIDA, Jumpei; IKEDA, Shuhei; KUSUMOTO, Tomokazu; SUGIYAMA, Hideyuki; TOKUHARA, Hidekazu; (170 pag.)US2016/318864; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary