Electric Literature of 937046-98-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 937046-98-5, name is 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, This compound has unique chemical properties. The synthetic route is as follows.
To a stirred suspension of Intermediate B (523 mg, 2.46 mmol), terf-butyl 4-(4,4,5,5- tetramethyl-1 ,3,2-dioxaborolan-2-yl)-3,6-dihydropyridine-1 (2H)-carboxylate (Eastwood, P. R. Tetrahedron Lett. 2000, 41, 3705) (950 mg, 3.07 mmol), and 1,1′- bis(diphenylphosphino)-ferrocene]dichloro palladium(ll)-complex with dichloromethane (180 mg, 0.25 mmol) in degassed DME (18 mL) was added aqueous Na2CO3 solution (2 M, 3.7 mL). The reaction was heated (80 0C) for 17 h and then cooled to rt. The mixture was partitioned between ethyl acetate (50 mL) and H2O (50 mL). The layers were separated and the organic layer was washed with brine (25 mL), dried (Na2SO4), and concentrated to dryness. The crude residue was purified by ISCO chromatography using a gradient of 50 to 75% ethyl acetate in hexanes to afford 584 mg (75%) of the desired product as an off-white solid, which contained trace impurities. 1H NMR (300 MHz, DMSO-d6) delta 7.85 (s, 1 H), 7.68 (br s, 2 H), 6.97 (br s, 1 H)1 6.87 (d, 1 H), 6.66 (d, 1H), 4.07-4.00 (m, 2 H), 3.53 (t, 2 H), 2.56-2.50 (m, 2 H), 1.42 (s, 9 H); ES-MS m/z 316.1 [MH-H]+, HPLC RT (min) 2.31.
The chemical industry reduces the impact on the environment during synthesis 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2007/56170; (2007); A2;,
Bromide – Wikipedia,
bromide – Wiktionary