One-pot synthesis of substituted dibenzoxazepinones and pyridobenzoxazepinones using octacarbonyldicobalt as an effective CO source was written by Anchan, Kavitha;Baburajan, Poongavanam;Puttappa, Nagaswarupa H.;Kumar Sarkar, Sujit. And the article was included in Synthetic Communications in 2020.Quality Control of 3-Bromo-4-fluorotoluene This article mentions the following:
A facile one-pot protocol for the synthesis of substituted dibenzoxazepinones I (R = H, 2-F, 2-Me, 3-OMe; R1 = H, 7-Me, 8-Cl, 9-Me, etc.) and pyridobenzoxazepinones II (R2 = H, 3-Me, 2-Me; R3 = H, 8,9-Cl2, 9-Me, 8-Cl, 9-Cl) from com. available aryl/heteroaryl halides 2-X-R4C6H3X1 (R4 = H, 4-F, 4-Me, 4-OMe; X = F, Cl; X1 = I, Br)/III (X2 = F, Cl; R5 = H, 5-Me, 6-Me) and amino phenols 2-NH-3-R6-4-R7-5-R8C6HOH (R6 = H, Me; R7 = H, Cl, ; R8 = H, Cl, Me) using octacarbonyldicobalt (Co2(CO)8) as an effective metal carbonyl source has been demonstrated. This method proceeds via the sequential coupling of aryl/heteroaryl halides with aminophenol by amidation and intramol. cyclization to give dibenzoxazepinones I/pyridobenzoxazepinones II. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Quality Control of 3-Bromo-4-fluorotoluene).
3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of 3-Bromo-4-fluorotoluene
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary