Adding a certain compound to certain chemical reactions, such as: 937046-98-5, name is 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 937046-98-5, Recommanded Product: 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine
Intermediate M4 7-Bromo-5-chloropyrrolo[ 1 ,2-f] [ 1 ,2,4]triazin-4-amine To a solution of 7-bromopyrrolo[2, l-fJ[l,2,4]triazin-4-amine (0.48 g, 2.253 mmol) in DMF (11.27 ml) was added NCS (0.361 g, 2.70 mmol) and the reaction mixture was stirred at room temperature for 2 days and was monitored by LCMS. The reaction mixture was partitioned between 1.5M K2HPO4 and EtOAc. The organic phase was washed with 10% LiCl, brine, dried by Na2S04, filtered, and concentrated to afford a white solid as the crude product. The crude product was then purified by ISCO column (24g, 30-50-75% of EtOAc in hexane). The desired product was obtained as a white solid (0.48g) in 86% yield. Mass spectrum m/z 246.8, 248.8, 250.8 (M+H)+. XH NMR (400MHz, DMSO-d6) delta 8.17 (d, J=8.4 Hz, 1H), 7.93 (s, 1H), 7.21 – 7.00 (m, 1H), 6.98 (s, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BHIDE, Rajeev S.; RUAN, Zheming; CHERNEY, Robert J.; CORNELIUS, Lyndon A.M.; DHAR, T.G. Murali; GONG, Hua; MARCOUX, David; POSS, Michael A.; QIN, Lan-ying; SHI, Qing; TINO, Joseph A.; (126 pag.)WO2016/64958; (2016); A1;,
Bromide – Wikipedia,
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