Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain was written by Farina, Carlo;Gagliardi, Stefania;Ghelardini, Carla;Martinelli, Marisa;Norcini, Monica;Parini, Carlo;Petrillo, Paola;Ronzoni, Silvano. And the article was included in Bioorganic & Medicinal Chemistry in 2008.Recommanded Product: 3-Bromo-4-fluorotoluene This article mentions the following:
Chem. modifications of dimiracetam (I), a bicyclic analog of the nootropic drug piracetam, afforded a small set of novel derivatives that were investigated in in vivo models of neuropathic pain. Compounds 5, 7 and 8 displayed a very promising antihyperalgesic profile in rat models of neuropathic pain induced by both chronic constriction injury of the sciatic nerve and streptozotocin. The compounds completely reverted the reduction of pain threshold evaluated by the paw pressure test. Importantly these derivatives did not induce any behavioral impairment as evaluated by the rotarod test. These results suggest that compounds 5, 7 and 8 might represent novel and well-tolerated therapeutic agents for the relief of neuropathic pain. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Recommanded Product: 3-Bromo-4-fluorotoluene).
3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: 3-Bromo-4-fluorotoluene
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