In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3972-64-3, name is 1-Bromo-3-(tert-butyl)benzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 1-Bromo-3-(tert-butyl)benzene
I. 2-Bromo-4-tert-butylbenzenesulfonic acid (1)To a cooled (0¡ã C.) solution of commercially available 1-bromo-3-tert-butylbenzene (42.6 g; 199 mmol) in anhydrous dichloromethane (800 mL) was added chlorosulfonic acid (15.9 mL; 239.0 mmol) dropwise. After addition was complete, the reaction was stirred at 0¡ã C. for an additional 30 minutes, allowed to gradually warm to room temperature and further stirred overnight. The reaction mixture was concentrated under reduced pressure to about 500 mL and washed with aqueous hydrochloric acid (20 mL; 20N). The organic layer was separated and dried over magnesium sulfate which resulted in formation of a white precipitate. Methanol (200 mL) was added to dissolve the precipitate. The organic solution was filtered and concentrated under reduced pressure to yield the title product as a white solid (53.0 g).
The synthetic route of 3972-64-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Anderson, Eric C.; Biediger, Ronald J.; Chen, Jie; Dupre, Brian; Lory, Pedro; Market, Robert V.; Monk, Keith A.; Savage, Michael M.; Tennyson, Reginald; Young, Brandon M.; US2010/29753; (2010); A1;,
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