Neighboring-group effects on the rate of metal ion catalyzed decarboxylation of dimethyloxalacetic acid was written by Claus, Kenneth G.;Rund, John V.. And the article was included in Inorganic Chemistry in 1969.Application of 22426-14-8 This article mentions the following:
Some rates of the metal ion catalyzed reaction of dimethyloxalacetic acid to give 2-oxo-3-methylbutanoic acid and CO2 are reported. The catalysts are 1:1 complexes of 2-substituted 1,10-phenanthrolines with zinc (II) and manganese (II). In the complexes, the substituents are quite close to the metal ions and could affect the reaction rate by several modes of interaction with the metal or the substrate. The principal effect in zinc complexes is the result of the electron-donating power of the substituent. For manganese complexes, steric inhibition of the approach of the substrate to the metal ion seems to be more important. Some amine substituents are examined to see whether they may be able to react directly with the substrate. The syntheses for some new phenanthroline derivatives are reported. In the experiment, the researchers used many compounds, for example, 2-Bromo-1,10-phenanthroline (cas: 22426-14-8Application of 22426-14-8).
2-Bromo-1,10-phenanthroline (cas: 22426-14-8) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Application of 22426-14-8
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary