129316-09-2, name is 1,3-Dibromo-5-(tert-butyl)benzene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 129316-09-2
(4) (Suzuki) by Suzuki coupling reaction to obtain the final product f: the 9 – benzene anthracene -10 borate 10 mmol, 1, 3 – dibromo – 4, 6 – dihydro -5 – tert butyl 2 mmol, four (triphenylphosphine) palladium 0.4 mmol, toluene 80 ml, ethanol 20 ml, K2CO344 MmoL (for 20 ml distilled water into the solution), is added to the reaction bottle, then the system vacuum, in 110 C under the protection of nitrogen reflux 24 hours. After the completion of the reaction, methanol hot washing and filtering, toluene recrystallization, distillation to obtain the final product f. Yield 66%.
The synthetic route of 129316-09-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shaanxi Normal University; Hu Jianyong; Zhang Jiali; Zhao Zhen; Duan Xuewei; (18 pag.)CN109678645; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary