A Direct and Efficient Total Synthesis of the Tubulin-Binding Agents Ceratamine A and B; Use of IBX for a Remarkable Heterocycle Dehydrogenation was written by Coleman, Robert S.;Campbell, Erica L.;Carper, Daniel J.. And the article was included in Organic Letters in 2009.HPLC of Formula: 108940-96-1 This article mentions the following:
The total synthesis of the tubulin-binding agents (no biol. testing data presented) ceratamines A and B I (R = Me, H, resp., R1 = Me) was reported, along with des-Me analogs I (R = Me, H, R1 = H), via a synthetic route that is high-yielding and operationally efficient. The synthetic route involved a Beckmann rearrangement to form an azepine ring precursor, a Knoevenagel condensation to install the benzylic side chain, and an effective imidazole annulation onto an α-aminoketone precursor with a protected S-methylisothiourea. Final dehydrogenation proved remarkably facile using IBX. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1HPLC of Formula: 108940-96-1).
3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.HPLC of Formula: 108940-96-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary