Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells was written by Hampel, Sonja M.;Sidibe, Assitan;Gunaratnam, Mekala;Riou, Jean-Francois;Neidle, Stephen. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.COA of Formula: C13H14BrNO2 This article mentions the following:
A series of tetrasubstituted naphthalene diimide compounds I (n = 2-4) with N-methylpiperazine end groups has been synthesized and evaluated as G-quadruplex ligands. They have high affinity and selectivity for telomeric G-quadruplex DNA over duplex DNA. CD studies show that they induce formation of a parallel G-quadruplex topol. They inhibit the binding of hPOT1 and topoisomerase IIIα to telomeric DNA and inhibit telomerase activity in MCF7 cells. I has potent activity in a panel of cancer cell lines, with typical IC50 values of â?.1 μM, and up to 100-fold lower toxicity in a normal human fibroblast cell line. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4COA of Formula: C13H14BrNO2).
N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.COA of Formula: C13H14BrNO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary