Copper-Catalyzed Enantioselective Conjugate Addition of Grignard Reagents to Methyl 4,4,4-Trifluorocrotonate: Synthesis of Enantioenriched Trifluoromethylated Compounds was written by Zhang, Li-Ying;Zhou, Jia-Hui;Xu, Yun-He;Loh, Teck-Peng. And the article was included in Chemistry – An Asian Journal in 2015.Application of 14425-64-0 This article mentions the following:
Copper-catalyzed enantioselective 1,4-conjugate addition of Me 4,4,4-trifluorocrotonate with aliphatic Grignard reagents to access an asym. tertiary carbon center attached with a trifluoromethyl group was achieved under mild reaction conditions. The desired products were obtained in reasonable yields and good enantioselectivities. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Application of 14425-64-0).
1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application of 14425-64-0
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary