Preparation and Evaluation of 99mTc(CO)3-Labeled Pentadecanoic Acid Derivative and Its Suspension in Lipiodol was written by Satpati, Drishty;Pandey, Usha;Sarma, H. D.;Venkatesh, Meera;Banerjee, Sharmila. And the article was included in Cancer Biotherapy and Radiopharmaceuticals in 2009.Electric Literature of C15H29BrO2 This article mentions the following:
Transarterial embolization by the intra-arterial administration of 131I-lipiodol is a modality used in the treatment of liver cancer. Long-chain fatty acids, being highly lipophilic, are also known to localize in the liver, thus constituting favorable vectors for this modality of treatment. Toward this, we envisaged the derivatization of 15-bromopentadecanoic acid, rendering it suitable for incorporation of a tridentate chelating moiety, for radiolabeling with the [99mTc(CO)3(H2O)3]+ precursor. The complex prepared, being lipophilic, was expected to behave as a lipiodol surrogate. The radiolabeled complex could be obtained in >95% radiochem. yield, as characterized by high-performance liquid chromatog. The i.v. injection of the radiolabeled complex in mice resulted in 23.5% ± 4.3% uptake of injected dose (ID) organ in the liver at 3 h postinjection. However, the uptake of the lipiodol suspension of the complex at 3 h postinjection in the liver was found to be 43.8 ± 13.4% ID/organ, when injected via the portal vein. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Electric Literature of C15H29BrO2).
15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Electric Literature of C15H29BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary